Serankottai induced contact dermatitis during suthi process in Siddha -A case report

  • L Juliet Research Officer (Siddha)
  • SR Karthik Raja Research Associate
  • VL Reena Assistant Research Officer (Chemistry), Siddha Central Research Institute, Chennai, Tamilnadu, India
  • V Aarthi Research Officer (Siddha), Central Council for Research in Siddha, Chennai, Tamilnadu, India
  • P Rajeshwaran Sathiya Director i/c, Siddha Central Research Institute, Chennai, Tamilnadu, India
Keywords: ADR, Negative rechallenge, Pharmacovigilance, Semecarpus anacardium-nut, Suthimuraigal (Siddha purification process).


Background: In Siddha, the famous quote ‘Chukkuku pura nanju ,Kadukaiku aga nanju’, reveals that most of the plants are adjoined with the toxic part /chemical which has to be removed by the Suthi process before its medicinal uses. Any untoward medical occurrence during treatment is the ADR (Adverse Drug Reaction). Contact dermatitis is one of the common toxic symptoms/known ADR of most of the poisonous drugs. Serankottai (Semecarpus anacardium nuts- SA nuts) is enormously used in Siddha medicine for various challenging diseases like Rheumatoid arthritis, Cancer, Psoriasis, etc. This drug comes under poisonous herbs Schedule-E drugs and the expected adverse events are allergic contact dermatitis, redness, severe itching, burning sensation, facial edema, anasarca and anaphylactic reaction in extreme conditions. This study reports about the toxic signs developed by Serankottai and its management through Siddha medicines.

Methods: Reporting of a different case, presented with Contact dermatitis during Siddha purification method in Siddha manufacturing unit and the negative rechallenge of the symptoms by Siddha antidotes were discussed.

Results: It is to report that, Serankottai induced contact dermatitis has been successfully managed by proper Siddha antidotes like Puli ilai kudineer (Tamarind leaf decoction) and Sengal podi ottradam (Brick powder Fomentation) as mentioned in Gunapadam Mooligai Vagupu and Sattam Saarndha Maruthuvamum Nanju Maruthuvamum.

 Discussion: Proper purification of Toxic plants reduces toxicity to end user. Siddhars have documented step by step SOP in Purification of Toxic Plants. They have also prescribed remediation helping in Negative rechallenge. Here a case has been reported with Clinical manifestations like Blisters and boils after getting consent as per the CARE Guidelines to reveal the Negative rechallenge in pharmacovigilance.