A review on need of Vatsanabha (Aconitum ferox) Shodhana and its Pharmacovigilance concern
Introduction: Practice of Indian system of medicine is considered to be the safest form of therapy, however incidence of ADR owing to the consumption of traditional drug necessitates the introduction of Pharmacovigilance of ASU drugs. Vatsanabha is one such drug mentioned in various Ayurvedic formulation, on which many reports have been publishing regarding its ADR.
Methodology: A thorough literary review was carried out through various classical text books like Bhaishajyaratnavali, Bhavapraksha, Rasatarangini etc and various databases like Pubmed, science direct, Google scholar, Dhara using the key word Vatsanabha, ADR, Aconitum ferox, A total of 6 papers was found to be relevant and selected for the literary review.
Result:Reports are published regarding the ADR, like Hypotension, Bradycardia due to consumption of aconite based Ayurvedic medicine. Studies proved that the impact of Shodhana process in the classic method using cow’s urine is found to be more safe than any other purification methods. TLC studies shown that pseudoaconitine and aconitine were converted into less toxic substance like veratroyl pseudoaconine benzoylaconine respectively only through traditional Ayurvedic Shodhana.
Discussion: Vatsanabha is a toxic plant with Gunas like vikasi, vyavayi, sookshma etc in prominence. Purification method should be proper and in suitable medium so as to modify these Gunas and mitigate its noxious effect.
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