Drug Genuinity and its Role in Ayurvedic Pharmacovigilance W.S.R.T Pippali (Piper Longum)

  • Princy Xavier IIMD scholar, Dept. of Dravyaguna Vijanan, Govt. Ayurveda College Thiruvananthapuram


Background: Herbal preparations constitute the primary therapeutic interventions in Ayurveda. In Kerala more than 200 medicinal plants are taken on large scale for the preparation of medicinal products. Pippali is one among the drug which is used in almost all formulations. The genuinity, purity and quality of the drugs have direct impact on the quality of medicinal formulations. In the present study an attempt has made to ascertain the genuineness of fruit of Pippali in Kerala market, in concern with pharmacovigilance. 

Methods: Samples were collected randomly from different markets of Kerala. Genuiness of samples were analysed formacroscopic, microscopic and physicochemical parameters like total ash, water soluble extractives, TLC and HPTLC.

Results: Marked variations are noted in both macroscopic and microscopic characters. Instead of Piper longum, Piper retrofractum is using in many parts of Kerala. HPTLC was performed between the samples which showed marked differences in quantity of Piperine, which is a major chemical constituent of Pippali. Some of the samples does not matches with the parameter mentioned in API.

Conclusion: Standardisation of finished products can achieved only by the usage of genuine drugs. . The need of the hour is to take caution right from the collection of raw drug so as to avoid adulteration and substitution, which in turn prove that the AYUSH drugs are safe and scientific in global market.