Safety study of Baobarang (Embelia ribes Burm. f.)

  • Moin uddin . P.G. Scholar, Department of Ilmul Advia, A.K. Tibbiya College, A.M.U., Aligarh, UP, India
  • Nazish Siddiqui Associate Professor, Department of Ilmul Advia, A.K. Tibbiya College, A.M.U., Aligarh, UP, India
  • Sumbul Rehman Assistant Professor, Department of Ilmul Advia, A.K. Tibbiya College, A.M.U., Aligarh, UP, India.
Keywords: Baobarang, Safety study, WHO Guidelines, Heavy metals, Pesticide residues

Abstract

Background: Herbal Unani drugs represent an important class of traditional medicine system. According to WHO nearly 70-80% of world population relies on traditional medicines. Herbs are used for the treatment and prevention of various ailments. With increasing interest in herbal products there is an increasing concern over the herbal drugs safety. People assume that they are natural so they are safe but there are incidences of toxicity and adverse effects. Safety study of herbal drugs and food items is now mandatory as per WHO guidelines, to prevent the toxicity due to the material found in the soil and the environment.

Methods: Plants are vulnerable to be contaminated with harmful ingredients. It includes determination of Microbial load, Heavy metals by AAS, Aflatoxins LC-MS/MS and Pesticide Residues using GC-MS/MS. Therefore, the present study aimed to evaluate safety parameters in Baobarang (EmbeliaribesBurm. f.) belonging to the family Myrsinaceae.

Results: Safety study revealed the presence of heavy metals, lead, cadmium, mercury and arsenic within permissible limit as per WHO guide line while aflatoxin, pesticides  and microbial load were found to be absent in the crude drug sample.

Conclusion: From the safety profile obtained it can be concluded that  the test drug is safe for use and free from chances of toxicity

 

Author Biographies

Moin uddin ., P.G. Scholar, Department of Ilmul Advia, A.K. Tibbiya College, A.M.U., Aligarh, UP, India

 

 

Nazish Siddiqui, Associate Professor, Department of Ilmul Advia, A.K. Tibbiya College, A.M.U., Aligarh, UP, India

 

 

Sumbul Rehman, Assistant Professor, Department of Ilmul Advia, A.K. Tibbiya College, A.M.U., Aligarh, UP, India.

 

 

References

1. Jha & Pandey (2008; 3-14). Embeliaribes: Vidanga, Phytopharm.
2. Chopra, Nayar and Chopra (1999). Glossary of Indian medicinal plants. National Institute of Science Communication, CSIR New Delhi, 5th edition, pp.106-107.
3. Chopra, R.N., Chopra, I.C. and Varma B.S.(1969). Supplement to glossary of Indian medicinal plants. CSIR New Delhi. pp. 27-29.
4. Kapoor V K, Chawla A, Kumar M and Kumar P (1983). Anti-inflammatory agent in Indian Laboratories. Indian Drugs; 30: 481-488.
5. Publication. 1966: 796-799
6. Krishnaswamy and Purushothaman(1980). Antifertility properties of Embeliaribes, Ind.J.Exp.Biol, pp. 1359-1360.
7. William C.E.,Daphne E (2009). Trease and Evans Pharmacognosy Sixteenth Edition PP.337
8. Annonymous (2007). The Unani Pharmacopeia of India. Ministry of Health and Family Wel¬fare (New Delhi), Government of India; 1(1):84-5.
9. Usmani MI (2008). TanqeehulMufradat Famous offset Press Delhi, pp. 112-113.
10. Ghani, HN (2010). KhazainulAdvia, CCRUM, New Delhi, Vol I., pp.337-38.
11. Safiuddin HA (1979). UnaniAdviaMufradah, Council for Urdu Promotion, New Delhi, pp.189-190.
12. Mohd Ali (2008). Pharmacognosy And Phytochemestry; vol.1 , CBS Publisher And Distributors, New Delhi pp.389-391.
13. Nadkarni K.M. (2010). Indian plants and Drugs FirstEdition, Publish By Ajay Book Service, Darya Ganj, New Delhi.
14. Swamy H M K, Krishna V, Shankarmurthy K, Abdul rahiman B, Mankani K L and Mahadeven K M (2007). Wound healing activity of embelin isolated from the ethanol extract of leaves of EmbeliaribesBurm. J. Ethnopharmacol; 109: 529-534.
15. Kirtikar and Basu B.D. (1987). Indian Medicinal Plants, Second Edition, International Book Distributors, Dehradun.Vol.I, pp.1307-1309.
16. Ezeabara CA, Okanume OE, Emeka AN, Okeke CU, Mbaekwe EI (2014). Heavy Metal Contamination of Herbal drugs: Implication for Human Health-A Review, International Journal of Tropical Disease and Health. 4(10):1044-1058.
17. Lohar, D.R. (2007). Protocol For Testing Ayurvedic, Siddha and Unani Medicines, Govt. of India, Ministry of Health and Family Welfare, Pharmacopeal Laboratory for Indian Medicines, Ghaziabad, pp.22, 75, 87-93.
18. Anonymous (2005). The Unani Pharmacopoeia of India, Central Council for Research in Unani Medicine, New Delhi, Part I, Vol. I 84-85
19. Khurana N., Sharma R. K., Bhauria S. (2011). Microbiological Quality Assessment of Some Commercial Herbal Drugs, International Journal of Pharmaceutical Quality Assurance, 3(4):16.
20. Kunle, Folashade O., Egharevba, Omoregie H., Ochogu P. (2012). Standardization of Herbal Mrdicine- A Review, International Journal of Biodiversity and Conservation, Vol. 4(3):101-102
21. Keller N.P., Turner G., Bennett J.W. (2005). Fungal Secondary Metabolism- From Biochemistry to genomics. Nat. Rev. Microbiol. 3, 937-947.
22. Razzaghi A., Saberi M., Sharifan A., Rezaee M.B., Seifili R., Hosseini S.I. (2013). Effects of Heracleumpersicum Ethyl Acetate Extract on the Growth, Hyphal Ultrastructure and Aflatoxin Biosynthesis in Aspergillsparasiticus. Mycotox. Res.29, 261-269
23. Ventura M., Antonio G., Anaya I., Diaz J., Broto F., Agut M., Comellas L. (2004). Determination of Aflatoxins B1,G1,B2,G2,, in Medicinal Herbs by Liquid Chromatography- tandem Mass Spectrometry, Journal Chromatographya,. 1048(2):25-29.
Published
2020-06-30